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. Author manuscript; available in PMC: 2013 Feb 17.
Published in final edited form as: J Mol Biol. 2011 Dec 13;416(2):176–191. doi: 10.1016/j.jmb.2011.12.018

Fig. 1.

Fig. 1

Model of the RFC·ATPγS·PCNA complex and PCNA loading reaction. Crystal structure of RFC bound to ATPγS and a closed PCNA clamp10 and a computationally derived model of RFC bound to ATPγS and open PCNA.42 The MD model represents current thinking about PCNA opening in a right-handed spiral conformation to allow entry of DNA during RFC-catalyzed clamp loading on ptDNA (minimal pathway depicted on the right). Note: RFC-A, RFC-B, RFC-C, RFC-D, and RFC-E correspond to RFC-1, RFC-4, RFC-3, RFC-2, and RFC-5, respectively.