Table 2.
Adverse events in patients with advanced non-small cell lung cancer treated with erlotinib and pemetrexed
| Level 1 (n = 6) | Level 2 (n = 6) | |||||||
|---|---|---|---|---|---|---|---|---|
| Hematologic |
G1 |
G2 |
G3 |
G4 |
G1 |
G2 |
G3 |
G4 |
| Neutropenia/Leukopenia |
2 |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
| Thrombocytopenia |
2 |
1 |
0 |
0 |
1 |
1 |
0 |
0 |
| Anemia |
3 |
3 |
0 |
0 |
4 |
1 |
0 |
0 |
| Non-Hematologic |
G1 |
G2 |
G3 |
G4 |
G1 |
G2 |
G3 |
G4 |
| Nausea |
3 |
0 |
0 |
0 |
2 |
1 |
0 |
0 |
| Vomit |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
| Anorexia |
3 |
1 |
0 |
0 |
2 |
1 |
0 |
0 |
| Malaise |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
| Fatigue |
2 |
1 |
0 |
0 |
3 |
0 |
0 |
0 |
| Diarrhea |
1 |
0 |
0 |
0 |
1 |
0 |
1 |
0 |
| Constipation |
1 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
| Hiccup |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
| Oral mucositis |
1 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
| Rash |
2 |
2 |
1 |
0 |
1 |
5 |
0 |
0 |
| Pruritus |
1 |
0 |
1 |
0 |
2 |
0 |
1 |
0 |
| Paronychia |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
| Alopecia |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
| Peripheral Edema |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
| Alb |
4 |
1 |
0 |
0 |
1 |
2 |
0 |
0 |
| AST |
4 |
2 |
0 |
0 |
3 |
1 |
0 |
0 |
| ALT |
0 |
3 |
1 |
0 |
2 |
2 |
0 |
0 |
| ALP |
2 |
0 |
0 |
0 |
2 |
1 |
0 |
0 |
| Bilirubin |
1 |
0 |
0 |
0 |
2 |
1 |
0 |
0 |
| Na |
0 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
| K | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |