Table 1.
Group characteristics according to identification of dementia relative to MRIa : HAAS MRI sub-sample
| No dementia (n=347) | Future dementia (n=42) | Incident dementia (n=58) | Prevalent dementia (n=30) | p-value b | |
|---|---|---|---|---|---|
| Age [years] | 81.3 (5.0) | 82.7 (5.1) | 82.2 (4.9) | 84.2 (5.1) | 0.0082 |
| ICV [cm3] | 1436 (110) | 1429 (116) | 1440 (107) | 1442 (100) | 0.9525 |
| Education [years] | 10.4 (3.0) | 10.2 (3.1) | 9.9 (3.2) | 9.4 (2.6) | 0.2293 |
| CASI-score | 79.8 (9.8) | 72.5 (8.5) | 60.3 (16.2) | 44.8 (19.8) | < 0.0001 |
| CES_D score | 3.7 (3.5) | 4.5 (4.5) | 4.3 (2.2) | 3.0 (2.2) | 0.3172 |
| Bi-frontal distance | 0.34 (0.03) | 0.34 (0.04) | 0.36 (0.03) | 0.36 (0.03) | < 0.0001 |
| Striatum [cm3] | 20.0 (2.3) | 19.7 (2.6) | 18.9 (3.3) | 18.5 (2.0) | < 0.0004 |
| Accumbens [cm3] | 1.38 (0.24) | 1.26 (0.23) | 1.21 (0.28) | 1.08 (0.18) | < 0.0001 |
| Putamen [cm3] | 9.7 (1.2) | 9.4 (1.4) | 9.1 (1.7) | 8.7 (1.1) | < 0.0001 |
| Caudate nucleus[cm3] | 8.9 (1.3) | 9.0 (1.3) | 8.6 (1.7) | 8.7 (1.6) | 0.2972 |
| Hippocampus [cm3] | 5.6 (0.8) | 5.2 (0.7) | 4.9 (0.9) | 4.3 (0.9) | < 0.0001 |
| Apoliprotein E ε4 genotype [%] | 37 | 29 | 26 | 30 | < 0.0001 |
| Cerebral infarcts [%] | |||||
| 0 infarcts | 93 | 93 | 88 | 81 | |
| 1 infarcts | 6 | 7 | 7 | 15 | } < 0.0001 |
| ≥ 2 infarcts | 1 | 0 | 5 | 4 | |
| Lacune grade [%] | |||||
| 0 lacunes | 58 | 61 | 47 | 46 | |
| 1–2 lacunes | 31 | 34 | 32 | 35 | } < 0.0001 |
| 3–5 lacunes | 10 | 5 | 21 | 19 | |
| WMH grade [%] | |||||
| 0–3 | 75 | 71 | 60 | 46 | |
| 4–6 | 20 | 24 | 29 | 35 | } <0.0001 |
| 7–9 | 4 | 5 | 10 | 7 |
Abbreviations: MRI = Magnetic Resonance Imaging; ICV = Intra Cranial Volume; CASI-score = Cognitive Ability Screening Instrument - score; CES-D score = Center for Epidemiologic Studies Depression score; WMH grade = White Matter Hyperintensity grade.
a
All values are means with standard deviations in parenthesis, unless otherwise noted.
b
p-values are for the overall association of the characteristics to study group.