Table 2.
Effects of volume of striatum and hippocampus in model for prediction of cognitive decline
| Full sample (n=477) | No dementia sample (n=347) | ||||
|---|---|---|---|---|---|
| Model: | Effects a: | F-value | p-value | F-value | p-value |
| Hippocampus | HIPP quartiles | 9.8 | < 0.0001 | 5.4 | 0.0010 |
| Age * HIPP quartiles | 12.8 | < 0.0001 | 6.4 | 0.0003 | |
| N. accumbens | NACC quartiles | 14.9 | <0.0001 | 6.5 | 0.0002 |
| HIPP quartiles | 12.7 | < 0.0001 | 2.9 | 0.0352 | |
| Age * NACC quartiles | 17.1 | < 0.0001 | 7.3 | <0.0001 | |
| Caudate nucleus | CN quartiles | 0.6 | 0.6460 | 1.5 | 0.2186 |
| Hipp quartiles | 19.5 | < 0.0001 | 3.8 | 0.0101 | |
| Age * CN quartiles | 0.5 | 0.6512 | 1.5 | 0.2228 | |
| Putamen | PUT quartiles | 1.1 | 0.3644 | 1.6 | 0.1858 |
| HIPP quartiles | 15.8 | < 0.0001 | 3.7 | 0.0123 | |
| Age * PUT quartiles | 1.4 | 0.2540 | 1.7 | 0.1631 | |
| Striatum | STR quartiles | 1.4 | 0.2308 | 1.7 | 0.1607 |
| HIPP quartiles | 16.2 | < 0.0001 | 3.2 | 0.0227 | |
| Age * STR quartiles | 1.7 | 0.1577 | 1.7 | 0.1587 | |
Abbreviations: HIPP = hippocampus; NACC = nucleus accumbens; CN = caudate nucleus; PUT = putamen; STR = striatum.
a
Separate effects of age, education in years, gender, ICV, CES_D score, presence of cerebral infarcts, lacune grade, WMH grade, bi-frontal distance, and presence of ApoE 4 allele are not displayed.