. Author manuscript; available in PMC: 2013 Dec 11.

Published in final edited form as: ACS Comb Sci. 2012 Jun 11;14(7):403–414. doi: 10.1021/co300040q

Table 5.

Library Data for Compounds 3{106–122}


product 3	n	R³	building blocks	method	ion HRMS	calcd for HRMS	found HRMS	purity (%)^a	yield (%)^b
3{106}	1	4-MeOC₆H₄	5{2}	B	[M+H]⁺	340.1311	341.1320	>99	23
3{107}	1	4-MeOC₆H₄	5{6}	B	[M+H]⁺[-C₂H₄O₂]	394.1780	335.1642	99	34
3{108}	1	4-MeOC₆H₄	5{7}	B	[2M+H]⁺	393.1940	787.3894	98	16
3{109}	2	4-MeOC₆H₄	5{6}	B	[M+H]⁺[-C₂H₄O₂]	408.1937	349.1797	98	43
3{110}	2	3-MeOC₆H₄	5{9}	B	[2M+H]⁺	401.1627	803.3313	>99	31

3{111}	2	4-MeOC₆H₄	8{1}	E	[M+H]⁺[-C₂H₄O₂]	344.1260	285.1116	98	53^c
3{112}	2	4-MeOC₆H₄	8{2}	E	[M+Na]⁺	358.1416	381.1305	98	38
3{113}	2	4-MeOC₆H₄	8{5}	E	[M+Na]⁺	400.1886	423.1766	>99	46^c
3{114}	2	4-MeOC₆H₄	8{9}	E	[M+NH₄]⁺	464.1835	482.2159	95	11
3{115}	2	4-MeOC₆H₄	8{7}	E	[M+Na]⁺	443.1944	466.1744	96	44
3{116}	2	3-MeOC₆H₄	8{1}	E	[M+H]⁺[-C₂H₄O₂]	344.1260	285.1116	98	26
3{117}	2	3-MeOC₆H₄	8{2}	E	[M+Na]⁺	358.1416	381.1312	69	47
3{118}	2	3-thiophenyl	8{1}	E	[M+H]⁺[-C₂H₄O₂]	320.0718	261.0576	98	41
3{119}	2	3-thiophenyl	8{2}	E	[M+H]⁺[-C₂H₄O₂]	334.0875	275.0731	>99	34
3{120}	2	3-thiophenyl	8{3}	E	[M+Na]⁺	376.1344	399.1223	>99	28
3{121}	2	3-thiophenyl	8{7}	E	[M+Na]⁺	419.1403	442.1203	97	33
3{122}	2	3-thiophenyl	8{9}	E	[M+NH₄]⁺	440.1294	458.1622	98	28^c

UV purity determined at 214 nm after preparative HPLC.

Isolated yield after preparative HPLC

Isolated yield after column chromatography. Isolated desired products 3 were characterized by ¹H and ¹³C NMR spectroscopy (see the Supporting Information).