. Author manuscript; available in PMC: 2013 Dec 11.

Published in final edited form as: ACS Comb Sci. 2012 Jun 11;14(7):403–414. doi: 10.1021/co300040q

Table 6.

Library Data for Compounds 3{123–164}


product 3	n	m	R³	building blocks	method	ion HRMS	calcd for HRMS	found HRMS	purity (%)^a	yield (%)^b
3{123}	1	2	4-MeOC₆H₄	4{6}	A	[M+H]⁺	408.1573	409.1588	98	23
3{124}	1	2	4-MeOC₆H₄	4{17}	A	[M+H]⁺	382.1529	383.1538	92	41
3{125}	2	5	C₆H₅	4{11}	A	[M]⁺	418.2144	418.2156	99	46^c
3{126}	2	4	C₆H₅	4{18}	A	[M+Na]⁺	380.1624	403.1515	99	29
3{127}	2	2	4-Me₂NC₆H₄	4{12}	A	[M+H]⁺	420.2049	421.2125	95	53
3{128}	2	2	4-Me₂NC₆H₄	4{17}	A	[M+H]⁺	409.2001	410.2076	65	47

3{129}	1	2	4-MeOC₆H₄	5{4}	B	[M+H]⁺	370.1780	371.1851	97	46
3{130}	1	2	4-MeOC₆H₄	5{5}	B	[M+H]⁺	356.1634	357.1693	99	41
3{131}	1	2	4-MeOC₆H₄	5{6}	B	[M+H]⁺	396.1937	397.1997	98	7
3{132}	1	2	4-Me₂NC₆H₄	5{2}	B	[M+H]⁺	355.1784	356.1801	>99	23
3{133}	2	2	C₆H₅	5{2}	B	[M+H]⁺	326.1518	327.1530	99	76^c
3{134}	2	2	C₆H₅	5{6}	B	[M+NH₄]⁺	380.1988	398.2320	>99	58
3{135}	2	2	4-MeOC₆H₄	5{2}	B	[M+H]⁺	356.1624	357.1683	>99	8
3{136}	2	2	4-MeOC₆H₄	5{5}	B	[M+H]⁺	370.1780	371.1842	91	31
3{137}	2	2	4-Me₂NC₆H₄	5{5}	B	[M+H]⁺	383.2097	384.2105	98	46
3{138}	2	2	4-Me₂NC₆H₄	5{12}	B	[M+H]⁺	405.2052	406.2061	65	12
3{139}	2	2	4-Me₂NC₆H₄	5{7}	B	[M+H]⁺	422.2569	423.2581	96	23

3{140}	2	5	C₆H₅	7{3}	D	[M]⁺	415.2359	415.2370	99	47^c
3{141}	2	5	C₆H₅	7{4}	D	[M]⁺	470.2781	470.2793	>99	53^c

3{142}	1	2	4-MeOC₆H₄	8{11}	E	[M]⁺	362.1366	362.1354	99	67^c
3{143}	1	2	4-Me₂NC₆H₄	8{1}	E	[M]⁺	345.1576	345.1583	99	73^c
3{144}	1	2	4-Me₂NC₆H₄	8{6}	E	[M]⁺	442.2468	442.2470	97	35
3{145}	1	2	4-Me₂NC₆H₄	8{11}	E	[M]⁺	375.1682	375.1691	>99	85^c
3{146}	2	2	4-Me₂NC₆H₄	8{1}	E	[M]⁺	359.1733	359.1737	>99	76^c
3{147}	2	2	4-Me₂NC₆H₄	8{11}	E	[M]⁺	389.1838	389.1841	>99	81^c
3{148}	2	2	4-Me₂NC₆H₄	8{12}	E	[M]⁺	403.1995	403.2002	97	77^c
3{149}	2	2	3-MeOC₆H₄	8{1}	E	[M]⁺	346.1416	346.1423	>99	72^c
3{150}	2	2	4-MeOC₆H₄	8{1}	E	[M]⁺	346.1416	346.1423	99	81^c
3{151}	2	2	4-MeOC₆H₄	8{11}	E	[M]⁺	376.1522	376.1534	>99	76^c
3{152}	2	2	4-MeOC₆H₄	8{12}	E	[M]⁺	390.1679	390.1688	>99	74^c
3{153}	2	2	4-MeOC₆H₄	8{13}	E	[M]⁺	404.1835	404.1838	>99	68^c
3{154}	2	2	4-MeOC₆H₄	8{14}	E	[M]⁺	418.1992	418.2005	99	72^c
3{155}	2	2	3-thiophenyl	8{1}	E	[M]⁺	308.0718	308.0725	99	71^c
3{156}	2	2	3-thiophenyl	8{1}	E	[M]⁺	322.0875	322.0880	99	68^c
3{157}	2	2	3-thiophenyl	8{11}	E	[M]⁺	352.0981	352.0985	>99	78
3{158}	2	2	4-NCC₆H₄	8{12}	E	[M]⁺	385.1525	385.1534	98	66^c
3{159}	2	2	1-cyclohexenyl	8{1}	E	[M]⁺	320.1624	320.1632	-	71^c
3{160}	2	2	1-cyclohexenyl	8{11}	E	[M]⁺	350.1729	350.1737	-	82^c
3{161}	-	2	C₆H₅	8{11}	E	[M]⁺	348.1573	348.1580	-	37^c
3{162}	-	2	4-MeOC₆H₄	8{1}	E	[M]⁺	348.1573	348.1580	99	82^c
3{163}	-	2	4-MeOC₆H₄	8{11}	E	[M]⁺	378.1679	378.1686	99	82^c
3{164}	-	2	4-MeOC₆H₄	8{14}	E	[M]⁺	420.2148	420.2158	>99	82^c

UV purity determined at 214 nm after preparative HPLC.

Isolated yield after preparative HPLC.

Isolated yield after column chromatography. Isolated desired products 3 were characterized by ¹H and ¹³C NMR spectroscopy (see the Supporting Information).