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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Hum Immunol. 2012 May 28;73(8):811–817. doi: 10.1016/j.humimm.2012.05.009

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HLA-G gene structure and location of the six polymorphisms included in this study. Exon 1 encodes a signal peptide, exons 2 and 3 encode the 1 and 2 domains that form the peptide-binding cleft, exon 4 encodes the 3 domain that is involved in receptor binding, exon 5 encodes the transmembrane domain (Tm), and exons 6–8 encode the cytoplasmic domains.