Table 5.

HLA-G genotype association with sHLA-G concentration in the combined, controls-only, and cases-only cohorts. P-values were obtained for each polymorphism using either the Wilcoxon rank sum test or the Kruskal-Wallis test.

		Combined sample (n=97)			Controls-only (n=48)			Cases-only (n=49)
Polymorphism	Genotype
		n	Median sHLA-G, U/ml (interquartile range)	P	n	Median sHLA-G, U/ml (interquartile range)	P	n	Median sHLA-G, U/ml (interquartile range)	P
−725C/G/T	CC	66	21.1 (11.9–49.1)	0.0089	33	28.1 (14.7–58.8)	0.076	33	15.6 (10.2–36.2)	0.053
	CG	18	40.1 (22.6–67.0)		10	50.8 (32.3–72.8)		8	30.7 (19.1–57.6)
	CT	13	42.6 (22.7–76.3)		5	66.8 (30.4–104.8)		8	37.2 (20.6–46.6)
+36G/A	AA	37	23.6 (13.5–50.4)	0.87	18	38.8 (14.5–54.6)	0.89	19	17.1 (11.1–49.0)	0.81
	AG	41	32.7 (13.6–61.6)		23	43.0 (15.7–65.1)		18	23.9 (11.1–36.1)
	GG	19	28.1 (17.3–47.3)		7	28.1 (18.0–67.5)		12	26.4 (15.3–40.6)
1597 C	CC	81	28.1 (14.6–55.5)	0.73	39	41.3 (16.5–65.1)	0.51	42	22.5 (11.1–38.1)	0.99
	C	16	28.0 (11.8–47.5)		9	39.2 (13.9–46.1)		7	17.1 (11.2–49.0)
Thr258Met	Thr/Thr	74	26.2 (14.3–48.3)	0.48	36	37.8 (15.9–62.1)	0.17	38	22.6 (11.2–38.1)	0.67
	Thr/Met	20	34.4 (15.1–69.7)		11	51.9 (29.6–70.7)		9	20.9 (10.1–51.7)
	Met/Met	3	21.3 (14.0–49.7)		1	14.0		2	35.5 (21.2–49.7)
14bp indel	Ins/Ins	36	25.2 (13.8–49.6)	0.92	14	45.9 (17.9–63.6)	0.83	22	19.7 (11.2–38.6)	0.57
	Ins/Del	38	28.0 (14.3–62.7)		21	23.2 (15.3–64.2)		17	32.4 (11.9–45.3)
	Del/Del	23	28.6 (16.9–28.58)		13	38.4 (17.5–62.1)		10	22.8 (9.2–32.2)
+3142G/C	GG	49	26.8 (13.7–51.5)	0.95	23	41.3 (14.8–66.8)	0.72	26	19.9 (11.1–47.7)	0.74
	CG	35	32.4 (14.6–56.7)		19	37.2 (15.7–62.5)		16	31.6 (13.1–40.7)
	CC	13	24.2 (17.1–42.0)		6	37.7 (17.8–76.9)		7	21.4 (10.0–28.6)