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Cardiac contractility assay. Left ventricular developed pressure (LVDP, mm Hg) was determined in isolated hearts from WTD (n = 4) and KOD (n = 4) compared to WT (n = 5) and KO (n = 5) mice of both genders at the age of 3 months. Isoproterenol induced a significant increase in LVDP (a) A lower LVDP was registered in WTD and KOD relative to corresponding WT and KO. Half relaxation time (t1/2) was similar among the three conditions relative to WT. Values are average ± SEM, *P < 0.05.
