Fig. 3.

Histone acetylation status influenced by VPA in the liver regeneration process

N=4 for each group at each time point. Histone acetylation was detected with anti-acH3 antibody and compared with total H3 at 0, 12, 24, 36, 72, 120, or 168 h after 2/3 PH treatment with and without VPA (300 mg/kg, i.p. bid). (a) Western blot analysis of acH3; (b) Densitometric analysis of acH3. GAPDH was used as a loading control. ^* P<0.05,^** P<0.001, when the VPA(PH group is compared with the PH group at the same time point