Skip to main content
. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Nat Genet. 2012 Mar 25;44(5):502–510. doi: 10.1038/ng.2205

Figure 3. rs10784774 marks a monocyte specific cis-eSNP to LYZ and forms a monocyte specific master regulator of multiple genes including CREB1.

Figure 3

(a & b) rs10784774 is significantly associated with the expression of a probe mapping to the 3′UTR of LYZ, encoding lysozyme, in monocytes only (p 78 B-cell N.S., pmonocyte=8.9×10−78). (c) rs10784774 additionally forms an eSNP to 72 probes mapping across the genome, the most significantly associated being in the genes CREB1(p = 2.0×10−67), DUSP19 (p = 2.2×10−59), and RAB27A (p = 2.0×10−57). (d) Manhattan plot demonstrating chromosomal location of all genes with probes mapping to rs10784774. The blue line represents 1.0×10−11, red line 5.0×10−8.