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. 2012 Sep 5;26(9):1976–1985. doi: 10.1038/leu.2012.125

Figure 1.

Figure 1

Structure of the PML and RARA genes with the break point regions and the corresponding fusion gene transcripts. (a) The PML gene contains three well-defined small break point cluster regions (bcr's): bcr1 in intron 6, bcr2 in the downstream part of exon 6 and bcr3 in intron 3. In addition two rare break points in intron 7 have been reported. In the RARA gene the break points cluster in intron 2 (∼15 kb). (b) The three well-defined bcr's and the rare intron 7 breaks in the PML gene result in four different PML–RARA fusion transcripts. Percentages refer to the relative frequency of the various PML–RARA variants.