Table 2. Utility of ALOT markers.
|
Lineage markers |
||||
|---|---|---|---|---|
| Target antigen | Maturation markers | 1st level | 2nd level | Shared backbone markers |
| CyCD3 | T | T-ALL | ||
| CD45 | Immature | BCP-ALL/T-ALL/AML-MDS | ||
| CyMPO | My | |||
| CyCD79a | Ba | |||
| CD34 | Immature | BCP-ALL/AML-MDS | ||
| CD19 | Bb | BCP-ALL | ||
| CD7 | Tb | |||
| SmCD3 | Maturec | T-ALL | ||
Abbreviations: ALL, acute lymphoblastic leukemia; ALOT, acute leukemia orientation tube; AML, acute myeloblastic leukemia; B, B lineage; BCP, B-cell precursor; Cy, cytoplasmic; MDS, myelodysplastic syndrome; My, myeloid lineage; Sm, surface membrane; T, T lineage.
a
Also present in some T-ALL.
b
Also present in some AML.
c
SmCD3 is used as a maturity marker for T-lineage, as identification of suspected immature T-cells relies on detection of CyCD3+/lo SmCD3− CD34+/− blasts.