Table 6. Normal and reactive leukocyte populations in 120 CSF and 21 vitreous biopsies without evidence for lymphoma.
| Group of samples | % B-cells | SmIgκ/SmIgλ ratio | % T-cells | CD4/CD8 ratio | % Monocytes | % Neutrophilsa | % Other undefined events |
|---|---|---|---|---|---|---|---|
| CSF (n=120) | 2.0 (0-32) | 1.4 (1.0–3.0) | 50.8 (0–100) | 1.8 (0.1–10.9) | 2.1 (0–17) | 15 (0–99) | 31.7 (0–100) |
| CSF (MS cohort) (n=15) | 1.1 (0–4) | 1.3 (1.0–2.5) | 48.2 (0–89) | 2.8 (1.7–7) | 3.6 (0–14) | 23 (0–99) | 21.9 (0–100) |
| CSF (other HM suspicion) (n=9) | 0.2 (0–1) | NA | 40.8 (0–100) | 1.2 (0.2–3.5) | 0 | 9 (0–14) | 49.8 (0–100) |
| CSF (lymphoma suspicion) (n=96) | 4.8 (0–32) | 1.4 (1.0–3.0) | 63.4 (0–100) | 1.7 (0.1–10.9) | 2.6 (0–17) | 13 (9–59) | 23.4 (0–100) |
| Vitreous fluid (n=21) | 0.5 (0–4) | NA | 51.7 (3–100) | 2.1 (0.3–49) | 2.6 (0–14) | 18 (0–53) | 14.1 (0–100) |
Abbreviations: CSF, cerebrospinal fluid; HM, hematological malignancy; MS, multiple sclerosis; NA, not applicable due to lack of B-cells in most samples; Sm, surface membrane.
Results are expressed as mean value and range between brackets.
a
Cells that cluster based on FSCint/SSChigh/CD45lo can be considered as neutrophilic granulocytes (see also Discussion). NA, not applicable because of too few B-cells.