Table 1.
Functional Enrichment of the 24 most represented accessory domains. Domains were classified as “protein interaction domain” (according to Jin J. et al. [42]), “binding” (according to InterPro) or “other”; p-value was calculated by the DAVID web tool [49], using as input the list of all phosphatases and as background the whole proteome.
| Domain type | Count | p-Value | Class | Role |
|---|---|---|---|---|
| Rhodanese-like | 14 | 3,05E-18 | PTP | Other |
| NLI interacting factor | 7 | 2,94E-10 | HAD | Binding |
| Fibronectin, type III | 15 | 7,47E-04 | PTP | Protein interaction domain |
| RPEL repeat | 4 | 1,12E-04 | RS | Binding |
| GRAM | 5 | 1,61E-04 | PTP | Protein interaction domain |
| U2A’/phosphoprotein | 4 | 6,65E-04 | RS | Other |
| FERM | 5 | 9,98E-04 | PTP | Protein interaction domain |
| DEK | 3 | 1,32E-03 | PTP | Protein interaction domain |
| MAM | 4 | 2,31E-03 | PTP | Protein interaction domain |
| SH2 | 7 | 4,52E-02 | PTP,LP | Protein interaction domain |
| EF-HAND | 8 | 8,74E-02 | RS | Protein interaction domain |
| PH | 9 | PTP | Binding | |
| Ig-like | 15 | PTP | Protein interaction domain | |
| C2 | 9 | PTP | Protein interaction domain | |
| Arm repeat | 8 | RS | Protein interaction domain | |
| LR repeat | 6 | RS | Protein interaction domain | |
| Ank repeat | 5 | RS | Other | |
| Concavalin A-like | 4 | PTP | Protein interaction domain | |
| WD40 | 4 | RS | Protein interaction domain | |
| FHA | 3 | PTP,HAD,RS | Protein interaction domain | |
| HEAT | 3 | RS | Protein interaction domain | |
| Nucleic acid binding | 3 | PTP,LP | Binding | |
| PTB | 3 | PTP | Protein interaction domain |