Table 4.
Summary of pathway analysis from DAVID and the KEGG Pathway Database. Numbers in each trait column are the number of genes within each specific pathway
| Trait | |||||
|---|---|---|---|---|---|
| Global pathway | Subpathway | Pathway | ADG | AFI | RFI |
| Cellular processes | Cell Communication | Adherens junction | 1 | ||
| Gap junction | 2 | ||||
| Tight junction | 3 | ||||
| Cell growth and death | Apoptosis | 1 | 1 | ||
| Cell motility | Regulation of actin cytoskeleton | 1 | 1 | ||
| Transport and catabolism | Endocytosis | 2 | |||
| Lysosome | 3 | ||||
| Regulation of autophagy | 1 | ||||
| Environmental information processing | Signal transduction | Calcium signalling pathway | 1 | 3 | |
| MAPK signalling pathway | 1 | ||||
| Notch signalling pathway | 2 | ||||
| Phosphatidylinositol signalling system | 1 | ||||
| TGF-beta signalling pathway | 2 | ||||
| Wnt signalling pathway | 1 | ||||
| Signalling molecules and interaction | Neuroactive ligand–receptor interaction | 3 | |||
| Genetic information processing | Folding, sorting and degradation | Proteasome | 1 | ||
| RNA degradation | 1 | ||||
| Ubiquitin-mediated proteolysis | 2 | ||||
| Transcription | Spliceosome | 1 | |||
| Translation | Aminoacyl-tRNA biosynthesis | 1 | |||
| Human Diseases | Cancers | Acute Myeloid Leukaemia | 1 | ||
| Chronic Myeloid Leukaemia | 1 | ||||
| Pancreatic cancer | 1 | ||||
| Pathways in cancer | 2 | 1 | |||
| Prostate cancer | 1 | ||||
| Small cell lung cancer | 1 | ||||
| Thyroid cancer | 1 | ||||
| Cardiovascular diseases | Viral myocarditis | 3 | |||
| Infectious diseases | Epithelial cell signalling in Helicobacter pylori infection | 1 | |||
| Metabolic disorders | Type II diabetes mellitus | 1 | |||
| Neurodegenerative diseases | Alzheimer's disease | 2 | 1 | 1 | |
| Huntington's disease | 1 | 2 | |||
| Metabolism | Amino acid metabolism | Phenylalanine metabolism | 1 | ||
| Tyrosine metabolism | 1 | ||||
| Carbohydrate metabolism | Inositol phosphate metabolism | 1 | |||
| Energy metabolism | |||||
| Glycan biosynthesis and metabolism | Keratan Sulphate Biosynthesis | 1 | |||
| N-Glycan biosynthesis | 1 | ||||
| O-Glycan biosynthesis | 2 | ||||
| Lipid metabolism | Ether lipid metabolism | 1 | |||
| Glycerolipid metabolism | 1 | ||||
| Glycerophospholipid metabolism | 1 | ||||
| Metabolism of Terpenoids and Polyketides | Limonene and piene degradation | 1 | |||
| Nucleotide metabolism | Purine metabolism | 1 | |||
| Pyrimidine metabolism | 1 | ||||
| Organismal Systems | Circulatory system | Vascular smooth muscle contraction | 3 | ||
| Development | |||||
| Endocrine system | Adipocytokine signalling pathway | 1 | |||
| GnRH signalling pathway | 2 | ||||
| Insulin signalling pathway | 1 | ||||
| Melanogenesis | 1 | ||||
| Immune system | B cell receptor signalling pathway | 1 | |||
| Chemokine signalling pathway | 1 | 2 | |||
| Cytosolic DNA-sensing pathway | 1 | ||||
| Fc gamma R-mediated phagocytosis | 1 | ||||
| NOD-like receptor signalling pathway | 1 | ||||
| RIG-I-like receptor signalling pathway | 1 | 1 | |||
| T cell receptor signalling pathway | 1 | ||||
| Toll-like receptor signalling pathway | 1 | 1 | |||
| Nervous system | Long-term depression | 1 | 2 | ||
| Long-term potentiation | 1 | ||||
| Neurotrophin signalling pathway | 1 | 1 | |||