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. 2012 Apr;11(2):241–251. doi: 10.1111/j.1474-9726.2011.00781.x

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© 2011 The Authors. Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland

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Fig. 2 — Coronal sections of 11-week-old Nothobranchius furzeri stained for PCNA (red) and 5-ethynil-2′deoxyuridin (EdU) (green), 5 weeks after intraperitoneal EdU injection. Approximate position of the sections in panels A, B, H, I along the rostro-caudal axis of the brain is shown on top view of a whole-mount brain in the inset of panel A. (A) Coronal section of the telencephalon in median position: after 5 weeks, EdU+ cells migrate centrifugally from the ventricular and dorso-lateral margins into the parenchyma, outside of the PCNA+ proliferative regions. (B) Coronal section of a rostral portion of the optic tectum (OT): in the antero-dorsal margin (magnification in panel F) EdU+ cells form a strip into the tectal parenchyma well distinct from the PCNA+ cells area. (C–E) Magnifications of the dorsal, lateral, and ventricular margin of the telencephalic section, respectively, represented in pictures A. (F, G) Magnifications of the antero-dorsal tectal margin and the III ventricle, respectively: in both cases, EdU+ cells migrate after 5 weeks into the parenchyma. (H, I) Coronal sections of the central and caudal portions of the OT: the antero-dorsal and postero-ventral strips of EdU+ cells into the parenchyma can be appreciated as well (red arrows); centripetally migrating EdU+ cells can be observed also in the torus longitudinalis (picture B, magnified panel F). A very large number of EdU+ cells can be found in the granule cell layer of the valvula cerebelli (picture H, magnified panel M) and corpus cerebelli (picture I, magnified panel N). Scale bar for magnification panels C, D, E, F, G, L, and M are the same as indicated in panel N.