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. 2012 Sep 10;3:324. doi: 10.3389/fmicb.2012.00324

Figure 5.

Figure 5

Amino acid sequence comparision of Juruin (Aju1a) to other ICK-containing toxins. (A) Multiple sequence alignement of Juruin to selected toxins. Amino acid sequences of toxins were retrieved from public databases and aligned with Muscle (Egdar, 2004). Cysteines are in yellow. To minimize confusion, all sequences are referred to by their UniProt accession numbers (http://www.uniprot.org/). Juruin (B3EWQ0), U3-theraphotoxin-Cj1a (B1P1A5), U3-theraphotoxin-Cj1a (B1P1A6), U3-theraphotoxin-Cj1b (B1P1A8), U3-theraphotoxin-Cj1b (B1P1A7), U3-theraphotoxin-Cj1c (B1P1A9) from Chilobrachys jingzhao. U1-theraphotoxin-Ba1b (P85504), U1-theraphotoxin-Ba1a (P85497) from Brachypelma ruhnaui. U1-theraphotoxin-Bs1a (P49265) from Brachypelma smithi. U1-theraphotoxin-Asp1b (P61510), U1-theraphotoxin-Asp1a (P61509) from Aphonopelma californicum. Putative mature sequence toxin-like RFEC (D5J6X7), putative mature peptide toxin-like LFEC (D5J6X5) from Pelinobius muticus. U1-theraphotoxin-Lp1b (P61506) from Lasiodora parahybana. Hainantoxin-II-17 (D2Y2D4), Hainantoxin-II-15 (D2Y226) from Haplopelma hainanum. Huwentoxin-7 (P68421), U1-theraphotoxin-Hh1a (P82959), HWTX-VIII (B5U1K0), HWTX-II (B3FIU5), HWTX-VIIIa (B3FIT5), HWTX-IIb (B3FIS9), HWTX-IIa (B3FIS8), U1-theraphotoxin-Hh1f (P68422), Huwentoxin-2a (Q86C49), HWTX-VIIb (B3FIT3), HWTX-VIIa (B3FIT2) from Haplopelma schimidti. (B) Amino acid occurrence within selected toxins. (C) Structural similarity of Juruin to that of U3-theraphotoxin-Cj1a, from Chilobrachys jingzhao, to which Juruin shares 80% sequence similiarity. Conserved residues are shown in black boxes.