Table 1.
Antimicrobial activities of cysteine-rich antimicrobial peptides against selected microorganisms.
| MIC [μM (μg/mL)] | Juruin | Gomesin | Amphotericin B |
|---|---|---|---|
| GRAM-POSITIVE BACTERIA | |||
| Micrococcus luteus A270 | ND | 0.4 (0.88) | ND |
| Staphylococcus aureus ATCC 29213 | ND | 1.2 (2.6) | ND |
| Staphylococcus epidermidis ATCC12228 | ND | NT | ND |
| GRAM-NEGATIVE BACTERIA | |||
| Escherichia coli SBS363 | ND | 0.4 (0.88) | ND |
| Escherichia coli ATCC 25922 | ND | 0.9 (1.9) | ND |
| Pseudomonas aeruginosa ATCC 27853 | ND | 5 (11) | ND |
| FILAMENTOUS FUNGI | |||
| Beauveria bassiana | ND | NT | 0.07-0.15 (0.06-0.13) |
| Aspergilus niger | 5–10 (20–40) | 1.2 (2.6) | 0.01–0.03 (0.01–0.03) |
| YEAST | |||
| Candida albicans MDM8 | 2.5–5 (10–20) | 1.25–2.5 (2.7–5.5) | 0.01–0.03 (0.01–0.03) |
| Candida krusei IOC 4559 | 2.5–5 (10–20) | 2.5–5 (5.5–11) | 0.07–0.15 (0.06–0.13) |
| Candida glabrata IOC 45658 | 2.5–5 (10–20) | >10 (22) | ND |
| Candida albicans IOC 45588 | 2.5–5 (10–20) | 5–10 (11–22) | ND |
| Candida parapsilosis IOC 456416 | 2.5–5 (10–20) | 2.5–5 (5.5–11) | 0.07–0.15 (0.06–0.13) |
| Candida tropicalis IOC 45608 | 2.5–5 (10–20) | 0.3–0.6 (0.6–1.2) | 0.07–0.15 (0.06–0.13) |
| Candida guilliermondii IOC 455716 | 2.5–5 (10–20) | 2.5–5 (5.5–11) | 0.07–0.15 (0.06–0.13) |
The activity of Juruin was compared to Gomesin (Silva jr. et al., 2000) and Amphotericin B. MIC values (μM) refer to the minimal inhibitory concentration required toachieve 100% growth inhibition. ND, not detected in the ranges assayed; NT, not tested.