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Attempted reaction conditions
| Entry | Base (equiv) | Conditions | Yield (%)a |
|---|---|---|---|
| 1 | Cs2CO3 (1.5) | DMF, MW, 120 °C, 30 min | 3 |
| 2 | Cs2CO3 (1.5) | DMF, MW, 140 °C, 30 min | 3 |
| 3 | Cs2CO3 (1.5) | DMF, MW, 160 °C, 30 min | 6 |
| 4 | K3PO4 (3) | NMP, MW, 160 °C, 20 min | 12b |
| 5 | K3PO4 (3) | NMP, MW, 180 °C, 20 min | 14b |
| 6 | K3PO4 (3) | NMP, MW, 200 °C, 20 min | 16b |
| 7 | K3PO4 (3) | NMP, 140 °C, 40 h | 26b |
Based on LC/MS analysis.
In addition to unreacted 3, several minor products (LC/MS) also present
