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. Author manuscript; available in PMC: 2013 Feb 3.
Published in final edited form as: Cell. 2012 Feb 3;148(3):399–408. doi: 10.1016/j.cell.2012.01.021

Table 2.

HIF Target Genes in Arterial Smooth Muscles in Pulmonary Hypertension

Target Gene(s) Protein Product(s) Consequence
EDN1 Endothelin Contraction
KCNA5, KCNB1 Voltage-gated K+ channels Increased [K+]i
TRPC1, TRPC6 Transient receptor potential Ca2+ channels Increased [Ca2+]i
NHE1 Sodium-hydrogen exchanger Increased pHi
PDK1 Pyruvate dehydrogenase kinase Glycolysis