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. 2012 May 1;20(9):1689–1698. doi: 10.1038/mt.2012.83

Figure 6.

Figure 6

Stability of T5.0002 in vivo in a human xenograft in nude mice. Tumors from five surviving mice that received CD vector (T5.0002) but no 5-FC in the experiment in Figure 5a were excised during killing (day 38), DNA prepared and the DNA examined using the PCR stability assay used in Figure 2 for retention of full-length IRES CD insert. The marker is shown on the left side and the positive control is U87 cells infected with the CD vector T5.0002 in the next lane. Numbers at the top are the numbers of the individual mice. CD, cytosine deaminase; IRES, internal ribosome entity site; 5-FC, 5-fluorocytosine.