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. Author manuscript; available in PMC: 2012 Dec 5.
Published in final edited form as: Mol Pharm. 2011 Oct 12;8(6):2012–2020. doi: 10.1021/mp200279p

Figure 6.

Figure 6

Growth rate of multiple myeloma in the bone marrow, effect of IL-6-independent replication rate. The figure above describes the growth rate of an initial MM tumor in the bone marrow for different values of doubling time in absence of IL-6 (11-32 days). The simulations show that germinal center translocations that lead to IL-6-independent cells generate tumors that grow much faster than those that are IL-6-dependent. Eventually the most aggressive tumors plateau due to hypoxia-induced quiescence, even though their growth continues to other niches of the marrow, there is an upper limit to the share of the marrow they may occupy (~15% for the parameters simulated).