Table 1.
Clinical and Demographic Characteristics
| HCQ (N=40) | No HCQ (N=217) | P Value | |
|---|---|---|---|
| Age at time of birth (Mean±SD) | 32.5 ±3.8 | 31.4 ± 4.6 | 0.23 |
|
| |||
| Cardiac-NL | 3 (7.5%) | 46 (21.2%) | 0.050 |
| 3rd degree and/or severe DCM/EFE | 1 (2.5%) | 40 (18.4%) | 0.036$ |
| 2nd degree or mild DCM/EFE | 2 (5.0%) | 6 (2.8%) | |
|
| |||
| Registry | |||
| U.S. | 15 (37.5%) | 166 (76.5%) | |
| FR | 20 (50.0%) | 32 (14.7%) | <0.001* |
| U.K. | 5 (12.5%) | 19 (8.8%) | 0.070* |
|
| |||
| Race/Ethnicity | 0.029 ** | ||
| White | 23 (57.5%) | 171 (78.8%) | |
| Black | 3 (7.5%) | 14 (6.5%) | |
| Hispanic | 3 (7.5%) | 9 (4.5%) | |
| Asian | 5 (12.5%) | 8 (4.0%) | |
| Other/NA | 6 (15.0%) | 15 (6.9%) | |
|
| |||
| Maternal Diagnosis | 0.0051 *** | ||
| Asym/UAS | 9 (22.5%) | 105 (48.4%) | |
| SS | 10 (25.0%) | 64 (29.5%) | |
| SLE | 16 (40.0%) | 28 (12.9%) | |
| SLE/SS | 4 (10.0%) | 18 (8.3%) | |
| MCTD | 1 (2.5%) | 1 (.5%) | |
| NA | 0 (0%) | 1 (0.5%) | |
|
| |||
| Antibody Status | 0.65 | ||
| Anti-Ro+/La + | 25 (62.5 %) | 144 (67.0%) | |
| Anti-Ro+/La− | 15 (37.5%) | 71 (32.7%) | |
| Anti-Ro+/La NA | 0 (0.0%) | 2 (0.92%) | |
|
| |||
| Sex of Child | 0.13 | ||
| Male | 14 (35.0%) | 101 (46.5%) | |
| Female | 24 (60.0%) | 103 (47.5%) | |
| NA | 2 (5.0%) | 13 (6.0%) | |
|
| |||
| Medications | |||
| Fluorinated Steroids | |||
| Total patients taking | 3 (7.5%) | 36 (16.6%) | 0.15 |
| Patients taking prior to cardiac-NL or 30 weeks gestation | 0 (0%) | 14 (38.8%) | 0.54 |
| Non-fluorinated steroids | |||
| Total patients taking | 19 (52.8%) | 38 (18.8%) | <0.0001 |
| IVIG | 8 (20.0%) | 28 (12.9%) | 0.28 |
| Plasmapheresis | 0 | 3 | 1.00 |
|
| |||
| Average Date of Birth | 8/2007 | 7/1999 | <0.0001 |
Age and hydroxychloroquine dosage are presented as mean with standard deviation. All other data are reported as N (%).
$
P value represents the comparison between HCQ and no HCQ eliminating the 2nd degree or mild DCM/EFE
*
P value represents comparison of FR and UK Registries to the US
**
P value represents the comparison of white to non white
***
P value represents the comparison of Asym/UAS to all others maternal diagnoses combined
Asym=Asymptomatic, UAS=Undifferentiated Autoimmune Syndrome, SLE=Systemic Lupus Erythematosus, SS=Sjogren’s Syndrome, MCTD=Mixed Connective Tissue Disease, DCM = Dilated Cardiomyopathy, EFE = Endocardial Fibroelastosis, NA=Not Available