Table 3.

Unadjusted and Adjusted Odds Ratios for Risk Factors of Recurrent Cardiac-NL

Variable	OR (95% CI)^*	P-value	OR_adj (95% CI)^**	P-value	OR_adj (95% CI)^***	P-value
HCQ
No	1 (ref)		1 (ref)		1(ref)
Yes	0.30(0.09–1.00)	0.050	0.23(0.06–0.92)	0.037	0.10(0.014–0.70)	0.020
Maternal Age at Time of Birth	1.01(0.93–1.09)	0.91
Maternal Race
Non-White	1		1		1
White	0.67 (0.29–1.56)	0.35	0.47(0.19–1.15)	0.099	0.55(0.21–1.45)	0.22
Maternal Diagnosis
Asym/UAS	1
SLE/SS/MCTD	1.33 (0.69–2.59)	0.38
Anti-SSB/La+
No	1		1		1
Yes	2.02(0.99–4.10)	0.052	2.06(0.98–4.37)	0.058	1.82(0.82–4.03)	0.14
Registry Source
U.S.	1		1		1
U.K.	0.97(0.30–3.10)	0.96	1.23(0.38–3.94)	0.73	1.41(0.43–4.61)	0.57
FR	1.78(0.84–3.80)	0.13	2.68(1.08–6.67)	0.03	2.06(0.79–5.32)	0.14
Sex of Child
Male	1
Female	0.64(0.33–1.22)	0.18
Prophylactic Fluorinated Steroid Use
No	1
Yes	0.64(0.13–3.15)	0.58
Non-Fluorinated Steroid Use
No	1
Yes	0.83(0.40–1.72)	0.61
IVIG
No	1
Yes	0.80(0.35–1.80)	0.59
Year of Birth	1.01(0.97–1.06)	0.51

estimates of unadjusted Odds Ratios (OR) based on bivariate analyses with the 95% Confidence Intervals (CI) and corresponding p values.

^**

estimates of adjusted OR with 95% CI and corresponding p value from a multivariable GEE model including hydroxychloroquine (HCQ) use, maternal race, the presence of anti-SSB/La antibody, and Registry source

^***

Asym=Asymptomatic, UAS=Undifferentiated Autoimmune Syndrome, SLE=Systemic Lupus Erythematosus, SS=Sjogren’s Syndrome, MCTD=Mixed Connective Tissue Disease