Figure 2.

NPS effects on cocaine reinstatement are mediated by CRF₁. SA, Mean of the 3 last days of self-administration; Ext, mean of the 2 last days of extinction; Sal, saline injection. A, B, Lever pressing in C57BL/6J mice pretreated with vehicle or antalarmin followed by saline or NPS (N = 9) (A) and in WT and CRF₁ KO mice treated with saline or NPS (N = 12) (B). The data are represented as means ± SEM. Statistical significance was calculated by ANOVA and Bonferroni's corrections were made for the subsequent pairwise comparisons such that significance was set at p < 0.0125. *Significant versus vehicle/saline.