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NPS increases locomotor activity through a CRF1-dependent mechanism. A, B, Locomotor activity in response to NPS after pretreatment with vehicle or antalarmin in C57BL/6J mice (N = 39) (A) and in CRF1 WT and KO mice (N = 27) (B). The data are represented as means ± SEM. Statistical significance was calculated by ANOVA and Bonferroni's corrections were made for the subsequent pairwise comparisons such that significance was set at p < 0.016. *Significant versus vehicle/saline.
