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. Author manuscript; available in PMC: 2012 Sep 10.
Published in final edited form as: Acta Neuropathol. 2011 Jun 1;122(3):285–292. doi: 10.1007/s00401-011-0843-x

Fig. 3. PSD-95 immunoreactivity in Hirano bodies in AD brains.

Fig. 3

a. PSD-95 (green) and tau (red) immunoreactivity with TO-PRO 3 counterstain (blue) in CA1 region of a control brain. PSD-95 immunoreactivity labels neuropil, while no tau positivity is detected. b. CA1 region of an AD brain shows tau positive neurofibrillary tangles (NFT, arrowhead) and dystrophic neurons (DN) and PSD-95 positive spindle-like Hirano bodies (HB, arrows). c. H&E stain shows an eosinophilic HB (arrow) in association with a neuron. b. A HB (arrow) is labeled with PSD-95 antibody with immunoproxidase-DAB reaction. e. A HB (arrow) is double-labeled with antibodies to PSD-95 and MAP2, a somatodendritic marker. f. A HB (arrow) is double-labeled with antibodies to PSD-95 and actin filament. Bar in b for a and b = 50 μm. Bar in f for c, d, e, and f = 20μm.