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. Author manuscript; available in PMC: 2012 Sep 10.
Published in final edited form as: J Med Chem. 2011 May 3;54(10):3661–3668. doi: 10.1021/jm101401a

Table 3.

ADME profiles of selected PMI inhibitors.

cmpd Solubility
pH 7.4
(µg/mL)		 Log Pea Plasma
Stabilityb
(mouse)		 Microsomal
Stabilityb
(mouse)
14 2.5 −2.8 10 62
17 22.5 −2.9 48 82.3
19 3.8 −3.2 99 85
20 11 −2.9 ND 81
a

Permeability determined by PAMPA assay.

b

Percent of compound remaining after incubation for 3 h (plasma) or 1 h (microsomes) at 37 °C.