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. 2004 Jan;24(2):487–501. doi: 10.1128/MCB.24.2.487-501.2004

FIG. 6.

FIG. 6.

Residues 6 to 11 are critical to the activity of ΔNp73β. (A) Levels of induced expression of HA-ΔNp73β, ΔNp73β(Δ2-5), ΔNp73β(Δ6-11), and ΔNp73β(Neu) in H1299 stable cell lines are comparable. Western blot analysis was performed by using anti-p73 (Ab-3) monoclonal antibody. (B and H) ΔNp73β(Δ2-5) (B) and ΔNp73β(Neu) (H) are able to suppress cell growth in H1299 cells. (C and I) ΔNp73β(Δ2-5) (C) and ΔNp73β(Neu) (I) are able to induce cell death in H1299 cells. (D and J) ΔNp73β(Δ2-5) (D) and ΔNp73β(Neu) (J) are able to induce cell cycle arrest and apoptosis in H1299 cells. (E to G) ΔNp73β(Δ6-11) is incapable of inducing growth suppression (E), cell death (F), and cell cycle arrest and apoptosis (G) in H1299 cells.