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Identification of domains of Smad1 required for their interaction. (A) Diagram depicting the three domains: MH1, Linker region, MH2 within Smad1, and each expressing construct. (B) CHIP interacts with the MH2 domain of Smad1. Binding assay was performed with in vitro-translated 35S-labeled full-length or truncated Smad1 and GST-CHIP or GST protein alone. The lower panel shows the input of different truncated proteins used in the experiment.
