Table 2.
Interaction of FKBP5 Diplotypes and Childhood Trauma on the Brown-Goodwin Lifetime History of Aggression Scoresa
| CTQ | ||||||
|---|---|---|---|---|---|---|
| Variable | Emotional Abuse | Physical Abuse | Sexual Abuse | Emotional Neglect | Physical Neglect | Total |
| Abuse or neglect | ||||||
| F | 24.1 | 41.6 | 9.3 | 34.4 | 44.7 | 34.4 |
| P value | <.0001 | <.0001 | .003 | <.0001 | <.0001 | <.0001 |
| Age | ||||||
| F | 2.9 | 7.1 | 3.3 | 7.1 | 5.6 | 9.1 |
| P value | .10 | .01 | .06 | .01 | .02 | .003 |
| Axis I diagnosis | ||||||
| F | 10.5 | 9.9 | 6.7 | 11.5 | 20.5 | 25.3 |
| P value | .001 | .002 | .01 | .001 | <.0001 | <.0001 |
| Diplotype effect | ||||||
| F | 0.4 | 1.9 | 0.6 | 0.9 | 0.6 | 0.7 |
| P value | .66 | .15 | .55 | .40 | .51 | .48 |
| Gene-environment | ||||||
| F | 2.9 | 6.6 | 0.3 | 4.4 | 4.0 | 5.6 |
| P value | .05 | .001 (.005) | .73 | .01 (.033) | .02 (.033) | .004 (.012) |
| Whole model | ||||||
| F | 7.9 | 10.9 | 6.9 | 9.6 | 13.0 | 12.0 |
| r2 | 0.19 | 0.22 | 0.17 | 0.20 | 0.22 | 0.18 |
| P value | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 |
Abbreviation: CTQ, Childhood Trauma Questionnaire.
a
The values in parentheses represent P values after false discovery rate correction for multiple comparisons. There were 411 prisoners, of whom 185 do not have a history of childhood maltreatment: 91 experienced physical abuse, 58 sexual abuse, 67 emotional abuse, 91 emotional neglect, and 151 physical neglect. A total of 226 individuals experienced at least 1 form of abuse and/or neglect (CTQ total), and 181 had an Axis I diagnosis.