Skip to main content
. Author manuscript; available in PMC: 2012 Sep 10.
Published in final edited form as: Arch Gen Psychiatry. 2012 Jan;69(1):62–70. doi: 10.1001/archgenpsychiatry.2011.152

Table 4.

Interaction of Individual SNPs and Childhood Trauma on the BGHAa

SNP
Variable rs3800373 rs9296158 rs1360780 rs9470080
Gene effect
    F   1.7   0.1   1.0   0.7
    P value     .18     .89     .37     .49
Age
    F 14.0 17.1 13.2 13.0
    P value     .0002   <.0001     .0003     .0004
Axis I diagnosis
    F 33.2 31.2 37.1 30.6
    P value   <.0001   <.0001     .0001   <.0001
Abuse or neglect
    F 45.2 47.2 52.5 45.2
    P value   <.0001   <.0001   <.0001   <.0001
Gene-environment
    F   4.1   2.6   4.3   3.2
    P value     .017     .08     .015     .043
Whole model
    F 16.7 17.3 18.1 15.5
    r2   0.19   0.18   0.20   0.18
    P value   <.0001   <.0001   <.0001   <.0001

Abbreviations: BGHA, Brown-Goodwin Lifetime History of Aggression; SNP, single-nucleotide polymorphism.

a

Of 557 patients who completed the BGHA, 293 had experienced childhood abuse and/or neglect and 264 had experienced no abuse or neglect.

HHS Vulnerability Disclosure