Table 1.
Comparisons of coagulation measures between 132 patients with CRVO and 105 healthy, normal controls
| Coagulation measures (normal range) | Abnormal in CRVO | Abnormal in controls | P | OR, 95% CI |
|---|---|---|---|---|
| Homocysteine (≤13.5 μmol/L) | 15% (19/129) | 2% (2/102) | χ2 = 11.2, P = 0.0008 | 8.64, 1.96–38.0 |
| Free antigenic protein S (≥66%) | 9% (11/120) | 2% (2/92) | χ2 = 4.4, P = 0.04 | 4.54, 0.98–21.0 |
| Anticardiolipin antibody IgM (<10 MPL) | 11% (14/128) | 2% (2/104) | χ2 = 7.3, P = 0.007 | 6.26, 1.39–28.2 |
| Factor VIII (≤150%) | 20% (23/116) | 7% (7/98) | χ2 = 7.1, P = 0.008 | 3.22, 1.31–7.86 |
| Factor V Leiden mutation | 5% CTa (6/130) | 2% CT (2/104) | Fisher’s P = 0.3 | |
| Resistance to activated protein C (dated cutpoint) | 8% (9/112) | 5% (5/92) | χ2 = 0.53, P = 0.5 | |
| Prothrombin gene mutation | 3% CT (4/127) | 3% CT (3/105) | Fisher’s P = 1.0 | |
| Plasminogen activator inhibitor mutation | 28% 4G4G (36/127) | 26% 4G4G (26/100) | Mantel-Haenszel | |
| 46% 4G5G (59/127) | 43% 4G5G (43/100) | χ2 = 0.67, P = 0.4 | ||
| MTHFR C677T mutation | 22% CC (29/130) | 31% CC (31/101) | Mantel-Haenszel | |
| 35% CT (45/130) | 14% CT (14/101) | χ2 = 0.13, P = 0.7 | ||
| Antigenic protein C (≥73%) | 6% (7/127) | 7% (6/92) | χ2 = 0.10, P = 0.8 | |
| Antigenic protein S (≥63%) | 2% (3/125) | 4% (4/92) | Fisher’s P = 0.5 | |
| Antithrombin III (≥80) | 7% (8/121) | 2% (2/92) | Fisher’s P = 0.2 | |
| Anticardiolipin antibody IgG (<22 GPL) | 10% (13/127) | 7% (7/104) | χ2 = 0.89, P = 0.4 | |
| Plasminogen activator activity (≤21.1 U/mL) | 10% (11/107) | 10% (10/97) | χ2 = 0.0, P = 1.0 | |
| Lp(a) (<35 mg/dL) | 20% (25/123) | 20% (20/102) | χ2 = 0.02, P = 0.9 | |
| Resistance to activated protein C (dated cutpoint) | 8% (9/112) | 5% (5/92) | χ2 = 0.53, P = 0.5 | |
| Factor XI (<150%) | 4% (5/114) | 2% (2/96) | Fisher’s P = 0.5 | |
| Lupus anticoagulant | 10% (9/87) | 9% (7/81) | χ2 = 0.14, P = 0.7 |
Abbreviations: CI, confidence interval; C, mutant allele; OR, odds ratio; T, wild-type normal allele; Lp(a), lipoprotein a; CRVO, central retinal vein occlusion.