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. 2012 Mar 8;67(10):1014–1021. doi: 10.1093/gerona/gls008

Figure 2.

Figure 2.

(A) Homeostasis model assessment (HOMA) index scores for insulin resistance in monkeys with lifetime exposure to a low-fat chow diet (n = 284; □), and subsets of middle-aged monkeys fed a high-fat western-type diet for 4 months (n = 24; ■) or 6 years (n = 9; ■). Chronic nutritional stress with a high-fat diet was required to significantly increase HOMA scores (unlike letters indicate p < .05 for the comparison). (B) Muscle HSP70 protein levels in monkeys with lifetime exposure to a low-fat chow diet (n = 284; □) and subsets of middle-aged monkeys fed a high-fat western-type diet for 4 months (n = 24; ■) or 6 years (n = 9; ■). Short-term high-fat western diet exposure increased muscle HSP70 by 72%. However, after chronic nutritional stress, the high-fat diet-induced insulin resistance and depressed HSP70 levels by 77% (unlike letters indicate p < .05 for the comparison). (C) Representative Western blot of HSP70 and GAPDH, demonstrating a positive control (PC) and a random selection of monkey samples. The age of the individual monkey is indicated above each lane.