Skip to main content
. Author manuscript; available in PMC: 2013 Oct 7.
Published in final edited form as: J Theor Biol. 2012 Jun 7;310:105–114. doi: 10.1016/j.jtbi.2012.05.032

Table 1.

Parameters used in model (Equation 3.1) and simulations. Initial conditions used in all simulations: I0 = 100, T0 = 1 × 106 for all 3 subjects and V0 = 3:5 × 102, 1 × 104, and 8 × 103 for subjects 1, 2 and 3, respectively

Parameter Definition Value Units

f(t) Activation function see text no unit
α Infection rate per
B-cell virus
fitted day−1 virion−1
EB Number of epithelial
cells susceptible to−1B-cell virus
see text cells
Vb Number of virus
released by B cells
7.3 × 104
(Hadinoto et al., 2009)
virions
β Infection rate per
epithelial-cell virus
fitted ml day−1 virion−1
EE Number of epithelial
cells susceptible to
epithelial-cell virus
fitted cells
k Rate of infected cells
killed by effector T cells
fitted, see text cell−1 day−1
δ Death rate of
infected cells
0.24
(Huynh and Adler, 2011a)
day−1
θ Rate of effector T cell
proliferation stimulated
by infected cells
fitted day−1
K Number of infected cells
when T cell proliferation
is half maximal
1000
(Huynh and Adler, 2011a)
cells
d Death rate of
effector T cells
0.0095
(Hadinoto et al., 2008)
day−1
P Virus production rate
by infected epithelial cells
173
(Hadinoto et al., 2009)
virions ml−1 day−1 cell−1
c Death rate of virus 2 (Shapiro et al., 2008) day-1