Table 1.

Parameters used in model (Equation 3.1) and simulations. Initial conditions used in all simulations: I₀ = 100, T₀ = 1 × 10⁶ for all 3 subjects and V₀ = 3:5 × 10², 1 × 10⁴, and 8 × 10³ for subjects 1, 2 and 3, respectively

Parameter	Definition	Value	Units
f(t)	Activation function	see text	no unit
α	Infection rate per B-cell virus	fitted	day−1 virion−1
EB	Number of epithelial cells susceptible to−1B-cell virus	see text	cells
Vb	Number of virus released by B cells	7.3 × 104 (Hadinoto et al., 2009)	virions
β	Infection rate per epithelial-cell virus	fitted	ml day−1 virion−1
EE	Number of epithelial cells susceptible to epithelial-cell virus	fitted	cells
k	Rate of infected cells killed by effector T cells	fitted, see text	cell−1 day−1
δ	Death rate of infected cells	0.24 (Huynh and Adler, 2011a)	day−1
θ	Rate of effector T cell proliferation stimulated by infected cells	fitted	day−1
K	Number of infected cells when T cell proliferation is half maximal	1000 (Huynh and Adler, 2011a)	cells
d	Death rate of effector T cells	0.0095 (Hadinoto et al., 2008)	day−1
P	Virus production rate by infected epithelial cells	173 (Hadinoto et al., 2009)	virions ml−1 day−1 cell−1
c	Death rate of virus	2 (Shapiro et al., 2008)	day-1