Table 2.
Characteristics of Circle participants by eGFR category and urine albumin (Ua) positivity (+/−) when eGFR = > 60
|
PARAMETER* (Mean values or %) |
eGFR Groups |
eGFR = < 90 |
eGFR 60 - < 90 |
eGFR = > 60 Total** |
eGFR 30 - <60 |
eGFR <30 (no RRT) |
eGFR <15 RRT |
All eGFR < 60 = CKD-eGFR <60 |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Non-CKD (UA-) | CKD-alb (UA+) | p | Non-CKD (UA-) | CKD-alb (UA+) | p | Non-CKD (UA-) | CKD-alb (UA+) | p | Stage 3 CKD | p vs Non-CKD | Stage 4/5a CKD | p vs Non- CKD | Stage 5b CKD | p vs Non- CKD | Stage 3-5b CKD | p vs Non- CKD | |
| NUMBER |
715 |
147 |
220 |
… |
95 |
121 |
… |
242 |
341 |
… |
105 |
… |
19 |
… |
8 |
… |
132 |
… |
| % FEMALE |
65.3 |
68.7 |
63.6 |
n/s |
71.6 |
56.2 |
|
69.8 |
61.0 |
0.017 |
72.4 |
n/s |
68.4 |
n/s |
12.5 |
0.002 |
68.2 |
n/s |
| AGE AT AUDIT |
55.6 |
47.6 |
49.4 |
n/s |
59.6 |
61.3 |
n/s |
52.3 |
53.6 |
n/s |
68.1 |
0.000 |
62.7 |
0.001 |
56.0 |
n/s |
66.6 |
0.000 |
| age diagnosis |
44.3 |
39.7 |
39.4 |
n/s |
49.9 |
48.1 |
n/s |
43.6 |
42.4 |
n/s |
53.0 |
0.000 |
42.2 |
n/s |
35.9 |
n/s |
50.4 |
0.000 |
| duration diabetes |
10.4 |
7.1 |
9.3 |
0.001 |
8.8 |
12.3 |
0.001 |
7.8 |
10.3 |
0.000 |
14.3 |
0.000 |
20.1 |
0.000 |
19.1 |
0.000 |
15.4 |
0.000 |
| BMI |
33.8 |
35.6 |
33.4 |
n/s |
34.8 |
33.7 |
n/s |
34.7 |
33.5 |
n/s |
33.3 |
n/s |
33.6 |
n/s |
27.5 |
0.004 |
32.9 |
0.033 |
| % SMOKER |
38.7 |
50 |
48.5 |
n/s |
30.4 |
27.3 |
n/s |
42.2 |
41.1 |
n/s |
23 |
0.001 |
27.8 |
n/s |
37.5 |
n/s |
26.2 |
0.002 |
| BLD PRESSURE |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| sBP (mm Hg) |
132.2 |
128.2 |
132.3 |
0.016 |
129.4 |
135.1 |
0.015 |
128.7 |
133.3 |
0.001 |
135.6 |
0.002 |
137.5 |
0.018 |
139.3 |
n/s |
136.1 |
0.000 |
| dBP (mm Hg) |
75.5 |
76.3 |
77.3 |
n/s |
75.4 |
74.9 |
n/s |
75.9 |
76.4 |
n/s |
72.2 |
0.002 |
74.05 |
n/s |
72.8 |
n/s |
72.5 |
0.002 |
| BLOOD TESTS |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| A1C (mean %) |
8.14 |
8.05 |
8.95 |
0.000 |
7.18 |
8.19 |
0.000 |
7.72 |
8.68 |
0.000 |
7.57 |
n/s |
7.65 |
n/s |
6.25 |
0.033 |
7.5 |
n/s |
| TC (mM) |
4.52 |
4.38 |
4.70 |
0.006 |
4.37 |
4.45 |
n/s |
4.38 |
4.61 |
0.008 |
4.48 |
n/s |
4.84 |
n/s |
4.66 |
n/s |
4.54 |
n/s |
| LDL (mM) |
2.38 |
2.34 |
2.44 |
n/s |
2.33 |
2.33 |
n/s |
2.33 |
2.40 |
n/s |
2.39 |
n/s |
2.6 |
n/s |
2.44 |
n/s |
2.43 |
n/s |
| HDL (mM) |
1.21 |
1.21 |
1.25 |
n/s |
1.19 |
1.18 |
n/s |
1.20 |
1.22 |
n/s |
1.23 |
n/s |
1.23 |
n/s |
1.04 |
n/s |
1.22 |
n/s |
| COMORBIDITIES |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| All Macrovasc (%) |
21.1 |
11.6 |
10.5 |
n/s |
23.2 |
25.6 |
n/s |
16.1 |
15.8 |
n/s |
38.1 |
0.000 |
68.4 |
0.000 |
62.50 |
0.005 |
43.9 |
0.000 |
| % periph vasc |
3.9 |
0.7 |
1.4 |
n/s |
3.2 |
5.0 |
n/s |
1.7 |
2.6 |
n/s |
4.8 |
n/s |
31.6 |
0.000 |
50.0 |
0.000 |
11.4 |
0.000 |
| % cerebro vasc |
5.3 |
2.7 |
2.7 |
n/s |
4.2 |
5.8 |
n/s |
3.3 |
3.8 |
n/s |
12.4 |
0.002 |
15.8 |
0.037 |
12.5 |
n/s |
12.9 |
0.001 |
| % combined heart |
16.1 |
9.5 |
7.3 |
n/s |
17.9 |
19.8 |
n/s |
12.8 |
11.7 |
n/s |
29.5 |
0.000 |
52.6 |
0.000 |
37.5 |
n/s |
33.3 |
0.000 |
| All Microvasc (%) |
22.4 |
11.6 |
23.2 |
0.003 |
11.6 |
25.6 |
0.007 |
11.6 |
24.0 |
0.000 |
32.4 |
0.000 |
47.4 |
0.000 |
87.5 |
0.000 |
37.9 |
0.000 |
| % foot disease |
4.6 |
2.0 |
5.0 |
n/s |
0.0 |
2.5 |
n/s |
1.2 |
4.1 |
0.034 |
8.6 |
0.002 |
21.1 |
0.001 |
37.5 |
0.000 |
12.1 |
0.000 |
| % eye disease |
13.8 |
6.1 |
13.6 |
0.015 |
9.5 |
15.7 |
n/s |
7.4 |
14.4 |
0.006 |
20.0 |
0.001 |
21.1 |
0.063 |
85.5 |
0.000 |
24.2 |
0.000 |
| % neuropathy |
12.7 |
6.1 |
13.2 |
0.021 |
7.4 |
14.0 |
n/s |
6.6 |
13.5 |
0.005 |
17.1 |
0.003 |
21.1 |
0.046 |
87.5 |
0.000 |
22.0 |
0.000 |
| MEDICATIONS |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| % Insulin |
30.1 |
18.4 |
33.2 |
0.001 |
21.1 |
38 |
0.005 |
19.4 |
34.9 |
0.000 |
30.5 |
0.018 |
57.9 |
0.000 |
75 |
0.001 |
37.1 |
0.000 |
| % RAAS agents | 75.2 | 63.3 | 76.8 | 0.004 | 73.7 | 85.1 | 0.028 | 67.4 | 79.8 | 0.001 | 81.9 | 0.004 | 63.2 | n/s | 62.5 | n/s | 78.0 | 0.019 |
* BMI-body mass index, sBP-systolic blood pressure, dBP-diastolic Blood pressure, A1C-glycosylated hemoglobin, TC-total cholesterol, LDL-LDL cholesterol, HDL-HDL cholesterol; periph vasc-peripheral vascular disease; cerebro vasc-cerebral vascular disease; combined heart- coronary artery disease and/or left ventricle hypertrophy and/or congestive heart failure. RAAS agents- containing angiotensin converting enzyme inhibitors or angiotensin receptor blockers.
**Total non-CKD is comparison group for all sub-groups and total with eGFR < 60.