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Targeted disruption of the LGR7 gene. (A) Schematic representation of the LGR7 locus, targeting construct, and mutant locus. Dark boxes represent exons of LGR7. The expected fragment lengths after VspI digestion are 9 kb for the wild type and 14 kb for the mutant allele. B, BamHI; V, VspI. (B) Targeted ES cells: Southern blot analysis of VspI-restricted DNA from clones L1, L2, L3, and L4; analysis was performed with a 3′ probe. M, marker.
