TABLE 1.
Overview of hematological and blood clotting parameters in control and LGR7 knockout micea
| Parameter and unitsb | Data for males of genotype:
|
Data for females of genotype:
|
||||
|---|---|---|---|---|---|---|
| +/+ | +/− | −/− | +/+ | +/− | −/− | |
| Red blood cells (1012/liter) | 9.29 ± 0.21 | 9.34 ± 0.13 | 9.35 ± 0.11 (5) | 9.39 ± 0.17 | 8.97 ± 0.19 | 9.44 ± 0.06 (4) |
| Hemoglobin (mmol/liter) | 8.97 ± 0.17 | 8.90 ± 0.07 | 8.74 ± 0.12 (5) | 9.25 ± 0.12 | 8.73 ± 0.10d | 9.19 ± 0.13 (4) |
| Hematocrit (liter/liter) | 0.461 ± 0.01 | 0.446 ± 0.01 | 0.449 ± 0.01 (5) | 0.460 ± 0.01 | 0.439 ± 0.00 | 0.461 ± 0.01 (4) |
| MCV (fl) | 49.7 ± 0.69 | 47.8 ± 0.39c | 48.0 ± 0.45 (5) | 49.0 ± 0.48 | 48.9 ± 0.58 | 48.8 ± 1.09 (4) |
| MCH (fmol) | 0.97 ± 0.01 | 0.95 ± 0.01 | 0.94 ± 0.01c (5) | 0.99 ± 0.01 | 0.97 ± 0.01 | 0.97 ± 0.02 (4) |
| MCHC (mmol/liter) | 19.5 ± 0.13 | 20.0 ± 0.18c | 19.5 ± 0.10 (5) | 20.1 ± 0.12 | 19.9 ± 0.14 | 20.0 ± 0.10 (4) |
| Reticulocytes | ||||||
| 109/liter | 378 ± 49 | 347 ± 41 | 331 ± 46 (5) | 355 ± 62 | 416 ± 48 | 273 ± 54 (4) |
| % RBC | 4.1 ± 0.6 | 3.7 ± 0.4 | 3.6 ± 0.5 | 3.8 ± 0.7 | 4.7 ± 0.6 | 2.9 ± 0.6 |
| White blood cells (109/liter) | 6.87 ± 0.68 | 7.04 ± 0.74 | 6.68 ± 0.41 (5) | 6.44 ± 0.60 | 5.00 ± 0.54 | 6.09 ± 0.93 (4) |
| Neutrophils | ||||||
| 109/liter | 1.04 ± 0.32 | 1.71 ± 0.67 | 0.83 ± 0.16 (5) | 0.51 ± 0.06 | 0.45 ± 0.04 | 0.55 ± 0.04 (4) |
| % WBC | 14.4 ± 4.1 | 21.9 ± 6.1 | 12.4 ± 2.0 | 8.4 ± 1.3 | 9.3 ± 0.9 | 9.5 ± 1.5 |
| Lymphocytes | ||||||
| 109/liter | 5.25 ± 0.57 | 4.65 ± 0.40 | 5.37 ± 0.42 (5) | 5.52 ± 0.60 | 4.24 ± 0.55 | 5.03 ± 0.81 (4) |
| % WBC | 77.3 ± 5.2 | 68.5 ± 7.1 | 80.1 ± 2.3 | 85.0 ± 1.6 | 83.8 ± 2.2 | 82.4 ± 1.8 |
| Monocytes | ||||||
| 109/liter | 0.49 ± 0.11 | 0.56 ± 0.12 | 0.37 ± 0.06 (5) | 0.27 ± 0.03 | 0.22 ± 0.08 | 0.34 ± 0.08 (4) |
| % WBC | 7.0 ± 1.4 | 7.8 ± 1.4 | 5.8 ± 1.2 | 4.5 ± 0.9 | 5.1 ± 2.0 | 5.7 ± 1.3 |
| Eosinophils | ||||||
| 109/liter | 0.09 ± 0.02 | 0.12 ± 0.03 | 0.11 ± 0.03 (5) | 0.14 ± 0.03 | 0.09 ± 0.02 | 0.16 ± 0.07 (4) |
| % WBC | 1.4 ± 0.3 | 1.9 ± 0.5 | 1.7 ± 0.4 | 2.1 ± 0.3 | 1.8 ± 0.3 | 2.4 ± 0.7 |
| Basophils (109/liter) | 0.00 | 0.00 | 0.00 (5) | 0.00 | 0.00 | 0.00 (4) |
| Thrombocytes (109/liter) | 893 ± 21 (5) | 930 ± 31 | 947 ± 50 (4) | 796 ± 50 (3) | 776 ± 60 | 732 ± 31 (3) |
a
Values represent means±standard errors of the means. Unless otherwise indicated in parentheses, the number of mice per group was six.
b
Abbreviations: MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MHCH, mean corpuscular hemoglobin concentration; RBC, red blood cells; WBC, white blood cells.
c
P value, <0.05.
d
P value, <0.01.