TABLE 2.
Overview of biochemical parameters in plasma from control and LGR7 knockout micea
| Parameter and unitsb | Data for males of genotype:
|
Data for females of genotype:
|
||||
|---|---|---|---|---|---|---|
| +/+ | +/− | −/− | +/+ | +/− | −/− | |
| ASAT (U/liter) | 59 ± 4.2 | 57 ± 3.4 | 43 ± 3.1c | 49 ± 3.7 (5) | 43 ± 0.7 | 45 ± 2.9 (5) |
| ALAT (U/liter) | 51 ± 4.2 | 42 ± 2.8 | 34 ± 3.0d | 33 ± 3.7 (5) | 27 ± 1.9 | 30 ± 2.1 (5) |
| Alk. Phos. (U/liter) | 89 ± 4.2 | 89 ± 3.4 | 110 ± 7.1c | 130 ± 7.6 (5) | 121 ± 13.2 | 146 ± 9.6 (5) |
| Bilirubin (μmol/liter) | 1.9 ± 0.3 | 1.6 ± 0.1 | 2.1 ± 0.1 | 2.1 ± 0.2 (5) | 2.1 ± 0.2 | 2.1 ± 0.3 (5) |
| Glucose (mmol/liter) | 8.7 ± 0.5 | 9.1 ± 0.4 | 8.9 ± 0.5 | 8.8 ± 0.3 (4) | 8.6 ± 0.8 | 7.7 ± 0.5 (5) |
| Urea (mmol/liter) | 11.1 ± 0.8 | 9.4 ± 1.0 | 9.7 ± 0.3 | 8.7 ± 0.6 (5) | 8.5 ± 1.1 | 9.4 ± 0.8 (5) |
| Triglycerides (mmol/liter) | 1.25 ± 0.14 | 1.11 ± 0.19 | 1.12 ± 0.10 | 0.72 ± 0.08 (5) | 0.73 ± 0.09 | 0.75 ± 0.15 (5) |
| Cholesterol (mmol/liter) | 2.60 ± 0.26 | 2.39 ± 0.12 | 2.32 ± 0.10 | 1.91 ± 0.16 (5) | 2.23 ± 0.26 | 1.91 ± 0.14 (5) |
| Total protein (g/liter) | 50.6 ± 1.4 | 52.4 ± 1.6 | 53.2 ± 1.4 | 50 ± 1.2 (4) | 51 ± 0.9 | 52 ± 0.9 (5) |
| Albumin (g/liter) | 29.7 ± 0.5 | 28.4 ± 0.6 | 30.1 ± 1.0 | 33.9 ± 0.8 (4) | 33.8 ± 0.3 | 34.4 ± 0.9 (5) |
| Creatinine (μmol/liter) | 12.0 ± 0.5 | 11.5 ± 0.8 | 10.8 ± 0.9 | 11.0 ± 0.7 (5) | 11.8 ± 1.0 | 11.0 ± 0.8 (5) |
| LDH (U/liter) | 263 ± 31 | 239 ± 18 | 200 ± 22 | 264 ± 61 (5) | 195 ± 27 | 206 ± 25 (5) |
| Creatinine kinase (U/liter) | 99 ± 13 | 108 ± 16 | 95 ± 12 | 122 ± 42 (5) | 106 ± 34 | 86 ± 13 (5) |
| Gamma GT (U/liter) | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 (5) | 0 ± 0 | 0 ± 0 (4) |
| Sodium (mmol/liter) | 156 ± 0.4 | 154 ± 0.8 | 155 ± 0.5 | 152 ± 0.4 (5) | 153 ± 0.5 | 153 ± 0.2d (5) |
| Potassium (mmol/liter) | 4.4 ± 0.2 | 4.6 ± 0.3 | 4.4 ± 0.1 | 4.2 ± 0.2 (5) | 4.0 ± 0.2 | 4.3 ± 0.1 (5) |
| Calcium (mmol/liter) | 2.37 ± 0.05 | 2.37 ± 0.04 | 2.43 ± 0.04 | 2.38 ± 0.02 (4) | 2.41 ± 0.02 | 2.37 ± 0.02 (5) |
| Choride (mmol/liter) | 112 ± 1.4 | 114 ± 0.8 | 111 ± 0.8 | 113 ± 0.6 (5) | 112 ± 1.0 | 113 ± 0.6 (5) |
a
Values represent means ± standard errors of the means. Unless otherwise indicated in parentheses, the number of mice per group was six.
b
Abbreviations: ASAT, aspartate aminotransferase; ALAT, alanine aminotransferase; Alk. Phos., alkaline phosphatase; LDH, lactate dehydrogenase; GT, glutamyl transpeptidase.
c
P value, <0.05.
d
P value, <0.01.