TABLE 4.
Fertility data of wild-type and homozygous male and female LGR7 mice
| Mating cross and ratioa | Generation/age | Pregnancy rate | Litter size | No. of pups found dead/live |
|---|---|---|---|---|
| WT M × WT F (1:1) | F3/11 wk | 6/6 | 9 ± 1 | 0/54 |
| WT M × WT F (1:1) | F3/4.5 mo | 6/6 | 7 ± 2 | 0/41 |
| KO M × WT F (1:2) | F2/14 wk | 8/24 | 8 ± 2 | 0/63 |
| KO M × WT F (1:1) | F2/7 mo | 7/11 | 9 ± 3 | 0/62 |
| KO M × WT F (1:1) | F3/4.5 mo | 4/6 | 10 ± 1 | 0/38 |
| KO M × KO F (1:1) | F3/11 wk | 5/8 | 9 ± 1 | 11/41b |
| WT M × KO F (1:1) | F2/14 wk | 8/8 | 10 ± 2 | 6/76b |
| WT M × KO F (1:1) | F3/11 wk | 5/5 | 9 ± 1 | 7/45b |
a
Abbreviations: WT, wild type; KO, knockout; M, male; F, female.
b
Pups died within 24 to 48 h; no milk was found in their stomachs.