FIG. 1.

Amino acid sequences of HDAC8. (A) Amino acid sequence of human HDAC8 (AF230097). Residues within the putative catalytic domain are highlighted in bold. Potential phosphorylation sites, as determined by phosphobase detection (http://www.cbs.dtu.dk/databases/PhosphoBase/predict/predict.html), are underlined. The potential PKA phosphorylation site (Ser³⁹) is marked with an asterisk. (B) Top, a potential PKA phosphorylation site in HDAC8 determined by database sequence analysis. Middle and bottom, comparison of the human HDAC8 sequence surrounding Ser³⁹ with other human class I HDAC sequences and with the mouse HDAC8 sequence.