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. 2004 Jan;24(2):899–911. doi: 10.1128/MCB.24.2.899-911.2004

FIG. 5.

FIG. 5.

Telomerase activity and telomere signals. (A) Comparison of telomerase activities in MEFs with and without Hsp70.1/3. Note that Hsp70.1/3−/− cells have a lower telomerase activity per unit of protein than do Hsp70.1/3+/+ cells and that the differences in telomerase activity are significant (P < 0.01). Ectopic expression of Hsp70.1 restored telomerase activity in Hsp70.1/3−/− cells, almost to the level in Hsp70.1/3+/+ cells. (B) Segments of metaphases from Hsp70.1/3+/+ and Hsp70.1/3−/− cells showing telomere FISH signals. Hsp70.1/3+/+ (a) and Hsp70.1/3−/− (b and c) cells were analyzed by FISH with a telomere-specific probe. Note the telomere associations (indicated by arrows in panel b) as well as breaks near telomeres (indicated by the arrow in panel c) in Hsp70.1/3−/− cells.