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. 2004 Jan;24(2):899–911. doi: 10.1128/MCB.24.2.899-911.2004

FIG. 6.

FIG. 6.

Influence of Hsp70.1/3 inactivation on cell survival after IR and heat-IR treatment. (A) Dose-response curves are shown for cells with and without Hsp70.1/3. Cells were treated with IR while growing exponentially and asynchronously. Hsp70.1/3−/− cells were more sensitive to cell killing by IR than were wild-type cells, and the differences are significant (P < 0.05). Cells were also subjected to heat treatment at 43°C for 30 min and then irradiated with different doses of IR. Hsp70.1/3−/− cells are more sensitive to cell killing after heat and IR treatment than are Hsp70.1/3+/+ cells. (B) Ectopic expression of Hsp70.1 in Hsp70.1/3−/− cells rescued the enhanced killing by IR or heat-modulated IR-induced cell killing.