Figure 4. A reconstructed metabolism composed of reactions imparted by metaconsensus enzyme functions.

Nodes represent reactants and products while the edges connecting them represent metaconsensus enzyme functions. The network is composed of 119 nodes and 135 edges. Reactions were assembled from the KEGG reactions database and small molecules and cofactors were removed. Yellow edges represent metaconsensus enzyme functions predicted by the universal sequence, universal structure, and universal reaction datasets. Green edges represent metaconsensus enzyme functions predicted by the universal sequence and universal structure datasets, but not the universal reaction dataset. Subnetworks circled in red roughly reflect subsets of metabolism related to amino acids and peptides, nucleotides and RNA, sugars and starches, and phospholipids. This reconstructed metabolism demonstrates that significant metabolic complexity is possible with only these ten metaconsensus enzyme functions.