Table 1. Metaconsensus enzyme functions and their associated metal and nucleotide cofactors.

Consensus	EC group	Enzyme description (abridged from EC)	Metal cofactors	Nucleotide-derived cofactors
Universal Sequence, Structure, and Function	1.3.1.-	Oxidoreductases. Acting on the CH-CH. NAD(+) as acceptor	Fe-S	FAD, FMN
	2.4.1.-	Transferases. Glycosyltransferases. Hexosyltransferases.	Ca, Mg, Mn	None
	2.7.1.-	Transferases. Transfering P groups. Alcohol acceptor.	Ca, Mg	None
	2.7.7.-	Transferases. Transfering P groups. Nucleotidyltranferases	Co, Mg	None
	4.1.2.-	Lyases. C-C bonds. Aldehyde-lyase.	Zn, Mg, Mn	FAD
	6.3.2.-	Ligases. C-N bonds. D-amino acid ligases.	Mg, Mn	None
Universal Sequence and Structure	3.1.2.-	Hydrolases. Ester bonds. Thiolester hydrolases.	Zn, Mg	None
	3.1.4.-	Hydrolase. Ester bonds. Phosphoric diester hydrolases.	Heme, Zn, Mg	None
	3.2.1.-	Hydrolase. Glycosylases. Glycosidases	Ca	None
	3.5.1.-	Hydrolases. C-N bonds (nonpeptide). Linear amides.	Ni, Co	ATP