Table 5. Alterations of expression between pre- and post-therapeutic tumours of patients with tumour regression grade (TRG) 2 and 3.

	TRG2		TRG3
Alteration	Gene	p-value1	Gene	p-value1
Increase
	NOTCH2	0.002	NOTCH2	0.062
	POU5F1	0.028	POU5F1	0.002
	LGR5	0.017
	CTNNB1	0.062
No change
	ABCG2	0.263	LGR5	0.249
	GSK3B	0.263	CTNNB1	0.733
	OLFM4	0.211	ABCG2	0.485
	CCND1	0.178	GSK3B	0.709
			OLFM4	0.961
Decrease
	DNMT1	0.009	CCND1	0.007
			DNMT1	0.002

¹Wilcoxon signed rank test.