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. 2012 Sep 10;7(9):e44552. doi: 10.1371/journal.pone.0044552

Figure 3. Estrogen prevents the IL-17 induced expression of osteoclastogenic cytokines in osteoblasts.

Figure 3

(A) Effect of E2 on IL-17 induced osteoclastogenic cytokine TNF-α was evaluated. (B) Effect of E2 on IL-17 induced IL-6 mRNA level. (C) Effect of E2 on IL-17 induced RANKL mRNA level. (D) Effect of E2 on IL-17 induced IL-17RA mRNA level. (E) Effect of E2 on IL-17 induced NF-kB translocation. Data represent three independent experiments and expressed as mean ± SEM with 95% confidence interval. Statistical analysis was performed by ANOVA method followed by the Newman–Keuls test of significance using Prism version 3.0 software.