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. 2012 Sep 10;7(9):e43632. doi: 10.1371/journal.pone.0043632

Figure 8. Comparison of expression of apoptotic proteins in 4a treated solid and liquid tumors in mice.

Figure 8

A. 4a was orally administered to mice bearing solid tumor (6 doses, 20 mg/kg). Tumor tissues were collected after 25 days of 4a treatment; lysate was prepared and used for western blotting. B. Expression of apoptotic proteins following 4a treatment in liquid tumor. EAC cells were injected intraperitoneally in mice to generate liquid tumor. Following 4a treatment (6 doses, 20 mg/kg) tumor cells were collected, lysate was prepared and used for western blotting. Antibodies used were BCL2, BAD, BAX, Phospho p53, p53, PCNA, CYTOCHROME C, FAS, FAS-L, FADD, CASPASE-8 and CASPASE-3. Actin was used as loading control (A, B).