Table 4. Percentage neutralization of IgG1s m43 and VRC01 against a panel of clade B isolates by pseudovirus assay using JC-10 and JC-53 as indicator cells.
IC50 (µg/ml) | Clade | Tropism | JC-10 cells | JC-53 cells | ||
m43 | VRC01 | m43 | VRC01 | |||
Bal | B | R5 | 160.83 | 0.04 | 17.52 | 0.03 |
JRFL | B | R5 | 174.67 | 0.13 | >200 | 0.14 |
JRCSF | B | R5 | 190.47 | 0.74 | >200 | 1.18 |
89.6 | B | Dual | 5.67 | 1.2 | 28.28 | 1.24 |
HxB2 | B | X4 | 0.2 | 0.07 | 0.2 | 0.1 |
VSV-G | >100 | >10 | >100 | >10 |